Type = API Reference,; Topic = Multienterprise Information Network Tower (MINT),;Persona = TraceLink Administrator, User,; Orchestration = Manufacturing, Logistics, Commerce,; Function = Supply Chain, IT, Procurement,

E222 purchase order APIs

An E222 Purchase Order is a digital document used to initiate the purchase of Schedule II controlled substances in compliance with DEA (Drug Enforcement Administration) regulations. It is part of the CSOS (Controlled Substance Ordering System) and serves as the electronic equivalent of the traditional DEA Form 222. The E222 Purchase Order contains a DEA-issued digital certificate that authenticates the buyer’s identity, verifies compliance with controlled substance regulations, and confirms the order is within permitted quantity limits. It also includes encrypted, digitally signed order data to ensure integrity and authenticity, along with information about the controlled substances being purchased, such as item codes, quantities, and supplier details. The file must be kept in its original form, as any modification can invalidate the signature and potentially delay order processing. By using the E222 Purchase Order, trading partners can securely exchange controlled substance orders through compliant B2B integrations, reduce paperwork, and speed up the ordering process. Its secure, validated format helps maintain regulatory compliance, protect supply chain integrity, and ensure timely fulfillment of sensitive products.

E222 purchase order (X12)

The E222 Purchase Order X12 message meets strict regulatory requirements while enabling secure, paperless ordering between authorized trading partners.

• Message Type: MPC_E222_PURCHASE_ORDER

• X12 Format: E222PURCHASEORDER

• Transform Names:

  • B2B_EDI_X12_850_E222_PurchaseOrder_IB_V1

E222 purchase order (Java)

The E222 Purchase Order Java message meets strict regulatory requirements while enabling secure, paperless ordering between authorized trading partners.

• Message Type: MPC_E222_PURCHASE_ORDER

• X12 Format: E222PURCHASEORDER

• Transform Names:

  • B2B_Java_E222_BinaryToBase64_IB_V1

  • B2B_Java_E222_Base64ToBinary_OB_V1

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